Effective Chemicals

.

UR-B597

UR-B597, UR-B597 for sale

Quantity Price
10 Grams $200
20 Grams $380
50 Grams $520
100 Grams $700
500 Grams $1400
1 Kilogram $2600

Minimum Order 10 Grams

Full Chemical Name: URB-597

Systematic IUPAC Name: [3-(3-Carbamoylphenyl)phenyl] N-cyclohexylcarbamate

CAS Number: 546141-08-6

ChemSpider Number: 1156960

Molecular Formula: C20H22N2O3

Molecular Mass: 338.41 g·mol−1

What is URB-597?

The enzyme fatty acid amide hydrolase (FAAH) is widely expressed in brain and other tissues and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.1 The enzyme fatty acid amide hydrolase (FAAH) is widely expressed in brain and other tissues and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.1 URB597 was recently synthesized and reported to be a potent and selective inhibitor of FAAH.2 URB597 inhibits FAAH with an IC50 of 4.6 nM in brain membranes and 0.5 nM in intact neurons. It has been demonstrated in FAAH(-/-) mice that marked depression of FAAH activity results in reduced sensation of pain and enhanced endocannabinoid signalling.3 URB597 exhibits both anti-nociceptive and anxiolytic effects in vivo without evoking other symptoms associated with cannabinoid-like compounds. Thus, URB597 may serve as a lead compound for the development of new analgesic and anxiolytic drugs.

.

.